Dynamic N6-methyladenosine RNA methylation in brain and diseases
نویسندگان
چکیده
منابع مشابه
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional...
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N-methyladenosine (mA) is themost prevalent internal (non-cap) modificationpresent in themessengerRNAofall higher eukaryotes. Although essential to cell viability and development, the exact role ofmAmodification remains tobedetermined.The recent discovery of twomAdemethylases inmammalian cells highlighted the importance of mA in basic biological functions and disease. Here we show that mA is se...
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ژورنال
عنوان ژورنال: Epigenomics
سال: 2020
ISSN: 1750-1911,1750-192X
DOI: 10.2217/epi-2019-0260